PI Name & Affiliation:

Dr. C. George Priya Doss,
Associate Professor
School of Bio Sciences and Technology (SBST)
Vellore Institute of Technology, India

Co-PI Name & Affiliation:

Dr. R. Gnanasambandan,
Assistant Professor (Senior)
School of Bio Sciences and Technology (SBST)
Vellore Institute of Technology, India

Dr. Karthik Gunasekaran,
Associate Professor (Grade I)
Department of Medicine, Unit-V
Christian Medical College (CMC), Vellore

Dr. I. Ramya,
Professor (Grade I)
Department of Medicine, Unit-V
Christian Medical College (CMC), Vellore

Funding Agency: ICMR

Scheme: Call for proposals on management and analysis of COVID-19 testing data

Overlay: Rs. 26,20,886

Duration of the Project: 2 Years

Dr. C. George Priya Doss

Dr. R. Gnanasambandan


solar

Project Description

SARS-CoV-2 is a member of a large family of viruses called coronaviruses that caused a tremendous danger to the worldwide pandemic, leading to millions of deaths. As of May 31, 2021, the WHO has proposed labeling the SAR-CoV-2 variants and the scientific terminology using Greek Symbols. Based on the increase in transmissibility and infection severity, the variants have been classified into Variants of Concern (VOC) and Variants Of Interest (VOI). WHO has categorized four variants as VOC, and eight variants come under VOI. Further, a predictor is highly required to distinguish strain types with the use of their genomic information. To mitigate this problem, we first proposed the framework of deep learning to diagnose the COVID19 based on simple clinical signs and symptoms using a gradient-boosting machine model built with decision-tree base-learners. Then 1D conventional neural network (CNN) will be used to predict the SARS-CoV-2 strain type from the genomic information of viruses underlying prediction with an alignment-free technique. Finally, to verify the efficacy of predictor, it has to be compared with other state-of-the-art prediction techniques based on Linear Discriminant Analysis, Random Forests, and Gradient Boosting Method.