PI Name & Affiliation:

Dr. Sudha Ramaiah
Associate Professor
School of Biosciences & Technology (SBST)
Vellore Institute of Technology, India

Co-PI Name & Affiliation:

Dr. Anand Manoharan
Nungambakkam, Chennai

Funding Agency: ICMR

Scheme: Adhoc

Overlay: Rs. 47,93,160

Duration of the Project: 3 Years

Dr. Sudha Ramaiah

Associate Professor


Project Description

At present there is an increasing prevalence of multi-drug resistance in Salmonella typhii. Gene network analysis will reveal the role of antibiotic resistance genes, and their associated functional partners in enhancing the resistance to antibiotics. The predominant action of functional partners will be identified. The topological metrics analysis will indicate that the involvement of clusters in their specific pathways and functions. Functional annotations of their gene products will provide valuable insights on drug resistance mechanisms. Our gene network model could be exploited for constructing similar networks for antibiotic resistance genes and for locating potential drug targets and unique candidate genes which can be targeted for drug discovery.