DBTFLC is a data repository and analytic platform emphasised on lung cancer specific human transcription factors which also are publicly sourced. Transcription factors, as we know, are key determinant for routine cellular function along with being overactive in cancer progression. The systematic collection and curation of transcription factors in lung cancer or its types is critically important for evaluation of their biological function as well as for developing therapeutic strategies. Intriguingly, we identified 349 transcription factors that were consistently plays a starring role in lung cancer.
The database enables discovery of relationships among:
Transcription factor-Transcription factor Network
Transcription factor-Target gene Network
All of these are provided and easily queried through search. Although there is still a need to study more about crucial role of transcription factors in lung cancer.Nevertheless, DBTFLC, we believe, is the only available database that provides the transcription factors and their features in lung cancer.