Patent Number Inventors Patents Title Country
TEMP/E-1/6696/2020-CHE Avtar Sain, Jayaprakash N.S. Cocktail of newly isolated lytic bacteriophages against multidrug resistant Salmonella and uses thereof India
201941038437A Priyankar Sen Budhaditya Bhattacharyya Alpha eco the next generation audio system India
PCT/IB2013/058490 Bilgimol C Joseph, Satheeshkumar, PK, Sukesh C Nair, Alok Srivastava, Vijayalakshmi MA Double mutant coagulation factor VIII and methods thereof USA & Europe
No. 3777/CHE/2012 Vignesh Narasimhan J., Sudheer Reddy A.R., Satheesh Kumar P.K., Krishnan V., Alok Srivastava, Sukesh C Nair, Vijayalakshmi M.A. Methods for producing recombinant peptides and protein from non-filamentous fungi and recombinant host cell thereof India
No. 5018 /CHE/2012 - Vignesh Narasimhan, Rajasekar R. Prasanna, Kamalanathan A.S., Vijayalakshmi M.A Monolith-Based Pseudo-Bioaffinity Purification Methods For Factor VIII From Various Sources And Application Thereof. India 2012
PCT/IB2013/060438 Vignesh Narasimhan, Rajasekar R. Prasanna, Kamalanathan A.S., Vijayalakshmi M.A Monolith-Based Pseudo-Bioaffinity Purification Methods For Factor VIII From Various Sources And Application Thereof. USA & Europe
No: 1137/CHE/2014 Reena Verma, Jayaprakash N.S, Vijayalakshmi. M.A, Krishnan Venkataraman Monoclonal antibodies against Plasmodium and uses thereof India
TEMP/E-1/26750/2015-CHE Prasanna Raja, A.S. Kamalanathan, V. Krishnan, M.A. Vijayalakshmi Pyrrole derivative as hypoglycemic agent India
IN-410166/ 2009 A.S. Kamalanathan Design of inhibitors for autoreactive antibodies with intrinsic protease like function from autoimmune sera India
IN-410165 / 2009 Ayeesha Noor Antidiabetic neutraceuticals from common plant India

Patents granted Inventors Title of Invention Patent No. and date of patent granted
1 Jisha John, Vijaya Krishna Kari, Yves Gnanou, Vijayalakshmi MA DENDRIMERS, CONJUGATES AND METHODS THEREOF US Patent No. 9,700,632; July, 11, 2017
2 Jisha John, Vijaya Krishna Kari, Yves Gnanou, Vijayalakshmi MA DENDRIMERS, CONJUGATES AND METHODS THEREOF Indian Patent No. 301223; Sep 20, 2018
3 Vignesh Narasimhan J., Sudheer Reddy A.R., Satheesh Kumar P.K., Krishnan V., Alok Srivastava, Sukesh C Nair, Vijayalakshmi M.A. METHODS FOR PRODUCING RECOMBINANT FACTOR VIII CHAINS FROM NON-FILAMENTOUS FUNGI, THEIR FUNCTIONAL RECONSTITUTION AND APPLICATIONS THEREOF U.S. Patent No. 9,708,387; July 18, 2017
6 Bilgimol C Joseph, Satheeshkumar, PK, Sukesh C Nair, Alok Srivastava, Vijayalakshmi MA DOUBLE MUTANT COAGULATION FACTOR VIII AND METHODS THEREOF European Patent No. EP 2897 634 Bl; Mar 21, 2018
7 Bilgimol C Joseph, Satheeshkumar, PK, Sukesh C Nair, Alok Srivastava, Vijayalakshmi MA DOUBLE MUTANT COAGULATION FACTOR VIII AND METHODS THEREOF Indian Patent No. 308682; Mar 6, 2019


  • Deora N, Sunitha MM, Harishankar SN, Vijayalakshmi MA, Venkataraman K*#, Venkateshan V*. Alleviation of diabetes mellitus through the restoration of β-cell function and lipid metabolism by Aloe vera (L.) Burm. f. extract in obesogenic WNIN/GR-Ob rats, Journal of Ethnopharmacology. 2021.272: 113921
  • Jyothilekshmi I and Jayaprakash N S. 2021. Trends In Monoclonal Antibody Production Using various bioreactor systems. J. Microbiol. Biotechnol. In Press 2021.
  • Boomathi Pandeswari P., Sabareesh V. An ESI Q-TOF study to understand the impact of arginine on CID MS/MS characteristics of polypeptides. Int. J. Mass Spectrom. 2021, 459, 116453.
  • Spoorthy N. Babu, S. Govindarajan, M.A. Vijayalakshmi, Ayesha Noor*. Role of Zonulin and GLP-1/DPP-IV in Alleviation Of Diabetes Mellitus by Peptide/Polypeptide Fraction of Aloe vera in Streptozotocin-Induced Diabetic Wistar Rats. Journal of Ethnopharmacology, Vol. 272, 2021, 113949.
  • Govindarajan S, Ayesha Noor*. Carbohydrate enriched fraction of Aloe vera extract suppresses inflammatory response through scavenging of oxidative stress and NO production in LPS-stimulated RAW 264.7 macrophages and adjuvant-induced arthritic rats via inhibition of pro-inflammatory cytokines. Indian Journal of Experimental Biology, Vol. 59, March 2021, pp. 177-185.
  • Govindarajan S., Ayesha Noor*. Biological Activities of Plant Polysaccharides, Mechanism of Action and Biomedical Applications: A Review. Research Journal of Biotechnology. (In Press).


  • Kamalanathan A.S. 2020, Occurrence of Nucleic acid hydrolyzing IgM antibodies in rheumatoid arthritis patients’ sera. Indian Journal of inflammation Research. 2020. In Press.
  • Sanjit Kumar 2020, Biochemical characterization of lactose binding Entadin lectin from entadin rheedii seeds with cytotoxic activity against cancer cell lines, ACS omega, In press.
  • Ganesh RA, Venkataraman K, Sirdeshmukh R. GPR56: An adhesion GPCR involved in brain development, neurological disorders and cancer. Brain Res. 2020 15;1747:147055. doi: 10.1016/j.brainres.2020.147055.
  • Ayesha Noor, 2020, Cu/TEMPO catalyzed dehydrogenative 1,3-dipolar cycloaddition in the synthesis of spirooxindoles as potential antidiabetic agents. RSC Adv. 10, 12262-12271.
  • Tetala, K. K. R., 2020, Simplification of affinity macroporous monolith microfluidic column synthesis and its ability for protein separation, J. Pharm. BioMed. Anal. 181, 113099. 
  • Priyankar Sen 2020, Pre-micellar concentrations of sodium dodecylbenzene sulphonate induce amyloid-like fibril formation in myoglobin at pH 4.5, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 586, 124240
  • Priyankar Sen 2020, Deciphering the role of premicellar and micellar concentrations of sodium dodecyl benzenesulfonate surfactant in insulin fibrillation at pH 2.0, International Journal of Biological Macromolecules, 148, 880-886.
  • Priyankar Sen 2020, Investigating the effect of food additive dye “tartrazine” on BLG fibrillation under in-vitro condition. A biophysical and molecular docking study, Journal of King Saud University-Science, 32, 3, 2034-2040.
  • Kamalanathan A S, Krishnan V., A dipyrrole derivative from Aloe vera inhibits an anti-diabetic drug target Dipeptidyl Peptidase (DPP)-IV invitro, Preparative Biochemistry and Biotechnology, 2020, 50 (5), 511
  • Sain A. Jayaprakash NS. Draft Genome sequence data of a T7like phage 3A_8767 isolated from wastewater of a butcher house near Palar River. Data Br. 2020; 105446. doi:10.1016/j.dib.2020.105446
  • Vishalkumar, P.1, Jayaprakash, N.S., Desai, P.K.1, Krishnan, V. and Vijayalakshmi, M.A.2020. Evaluation of anti-histidine-rich protein 2 monoclonal antibodies, developed by using poly (N-isopropylacrylamide) as an adjuvant for malarial diagnostic application. Tropical Biomedicine 37(4): 1050–1061 (2020)


  • Kamalanathan A.S. Vijayalakshmi, M.A, Venkataraman K. A 2019 dipyrrole derivative from Aloe vera inhibits an anti-diabetic drug target Dipeptidyl Peptidase (DPP)-IV in vitro. Preparative Biochemistry and Biotechnology, 5, 50, 511-520.
  • Kamalanathan AS, Venkataraman K. 2019 Modifications of human plasma Apolipoprotein A1 in systemic autoimmune diseases and myocardial infarction: A comparative study. Journal of Proteins and Proteomics 10: 235–243.
  • V. Sabareesh, 2019, "Hydrolysis of homocysteine thiolactone results in the formation of Protein-Cys-S-S-homocysteinylation" Proteins 87,8, 625 – 634.
  • Ayesha Noor 2019 Aloe barbadensis Miller peptide/polypeptide fraction alleviates inflammation through inhibition of proinflammatory cytokines and mediators in vitro and in rats with Freund’s adjuvant-induced hind paw edema. Asian Pacific Journal of Tropical Biomedicine 9(12):524-530.
  • Vijayalakshmi; Ayesha Noor. 2019 Evaluation of in vitro anti-diabetic and anti-oxidant activities and preliminary phytochemical screening of gel, epidermis and flower extract of Aloevera.  Research J. Pharm. and Tech., 68., Apr 2019; 12(4):1761-1768.
  • Venkataraman K, 2019, Recombinant irisin induces weight loss in high fat DIO mice through increase in energy consumption and thermogenesis. Biochem Biophys Res Commun. 2019;519(2):422-429.
  • Venkataraman K 2019. Development of anti-chloro (192) tyrosine HDL apoA-I antibodies for the immunodiagnosis of cardiovascular diseases. J Immunol Methods. 474:112637
  • Sanjit Kumar, 2019 Prospecting Potential Inhibitors of Sortase A From Enterococcus Faecalis: A Multidrug-Resistant Bacteria, Through In-silico and In-vitro Approaches Protein Pept Lett. doi: 10.2174/0929866527666191227143048. 
  • Sanjit Kumar 2019 Utilization of corona on functionalized selenium nanoparticles for loading and release of doxorubicin payload Journal of Molecular Liquids 296, 111864.
  • N.S. Jayaprakash, Sanjit K. 2019. Structural characterization of a unique peptide in porin: An approach towards specific detection of Salmonella enterica serovar Typhi". International Journal of Peptide Research and Therapeutics
  • V. Sabareesh. 2019. Middle-down approach: a choice to sequence and characterize proteins/proteomes by mass spectrometry. RSC Advances
  • Kamalanathan A S. 2019. An L-fucose specific lectin from Aspergillus niger isolated from mycotic keratitis patient and its interaction with human pancreatic adenocarcinoma PANC-1 cells. Int J Biol Macromol.
  • Ayesha Noor, Priyankar sen. 2019. Streptozocin; a GLUT2 binding drug, interacts with human serum albumin at loci h6DOM3-h7DOM3. International Journal of Biological Macromolecules.
  • Ayesha Noor. 2019. Evaluation of in vitro anti-diabetic and anti-oxidant activities and preliminary phytochemical screening of gel, epidermis and flower extract of Aloe vera. Research J. Pharm. and Tech
  • PRIYANKAR SEN. 2019. Millimolar concentration of sodium dodecyl sulfate inhibit thermal aggregation in hen egg white lysozyme via increased alpha-helicity. Colloids and Surfaces A: Physicochemical and Engineering Aspects
  • PRIYANKAR SEN. 2019. A quercetin-based flavanoid (rutin) reverses amyloid fibrillation in beta-lactoglobulin at pH 2.0 and 358K. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
  • PRIYANKAR SEN. 2019. Different conformational states of hen egg white lysozyme formed by exposure to the surfactant of sodium dodecyl benzenesulfonate. International Journal of Biological Macromolecules.
  • PRIYANKAR SEN. 2019. Allura red rapidly induces amyloid-like fibril formation in hen egg white lysozyme at physiological pH. International Journal of Biological Macromolecules


  • PRIYANKAR SEN, 2018. Trypsin Inhibitors from Cajanus cajan and Phaseolus limensis Possess Antioxidant, Anti-Inflammatory, and Antibacterial Activity, Journal of dietary supplements
  • PRIYANKAR SEN, 2018. An intermittent amyloid phase found in gemini (G5 and G6) surfactant induced β-sheet to α-helix transition in concanavalin A protein. Journal of Molecular Liquids
  • PRIYANKAR SEN, 2018, Unraveling the molecular mechanism of the effects of sodium dodecyl sulfate, salts, and sugars on amyloid fibril formation in camel IgG. Colloids and Surfaces B: Biointerfaces
  • PRIYANKAR SEN, 2018. Sodium louroyl sarcosinate (sarkosyl) modulate amyloid fibril formation in hen egg white lysozyme (HEWL) at alkaline pH: a molecular insight study. Journal of Biomolecular Structure and Dynamics
  • PRIYANKAR SEN, 2018. Unveiling the stimulatory effects of tartrazine on human and bovine serum albumin fibrillogenesis: spectroscopic and microscopic study. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
  • Krishnan V, 2018. Supplementation of glycine enhances the expression of recombinant anti-tnfα single chain variable fragment (scfv) in Escherichia coli. Asian Jr. of Microbiol. Biotech. Env. Sc.
  • Kamalanathan A S, 2018. Purification, characterization and fine sugar specificity of a N-Acetylgalactosamine specific lectin from Adenia hondala. Glycoconj J Kamalanathan A S, Krishnan, 2018. Efficient purification of Apolipoprotein A1 (ApoA1) from plasma by HEA HyperCel™: An alternative approach. J Chromatogr B Analyt Technol Biomed Life Sci.
  • S. Sreeja, Anand Manoharan and Krishnan Venkataraman. Oxidized lipoproteins as the diagnostic target for cardiovascular diseases. CURRENT SCIENCE, VOL. 115, NO. 7, 10 OCTOBER 2018
  • Venkatesh Padmanabhan, Sanjit Kumar and N.S.Jayaprakash, 2018. Structural characterization of a unique peptide in porin: An approach towards specific detection of Salmonella enterica serovar Typhi. International Journal of Peptide Research and Therapeutics. DOI 10.1007/s10989-019-09807-5.
  • M. A. Vijayalakshmi and Kishore K. R. Tetala. Nanomaterial Fused Monolithic Microcolumns for Biomolecule Separation Gen. Chem. 2018, 4, 180014. DOI: 10.21127/yaoyigc20180014
  • Muniyan Rajiniraja, Akella Sivaramakrishna, Varatharajan Sabareesh, Gurunathan Jayaraman. In vitro inhibition potential of mono-n-octyl phthalate on Mycobacterium tuberculosis H37Ra: Possibility of binding to mycobacterial PknB—An in silico approach. Biotechnology and Applied Biochemistry. July 2018, DOI: 10.1002/bab.1685
  • Rahul Pal, Saif Hameed, Varatharajan Sabareesh, Parveen Kumar, Sarman Singh, and Zeeshan Fatima. Investigations into Isoniazid Treated Mycobacterium tuberculosis by Electrospray Mass Spectrometry Reveals New Insights into Its Lipid Composition. Journal of Pathogens. Volume 2018, Article ID 1454316, 14 pages
  • Ngangoum Eric Serge1,2, Mezajoug Kenfack Laurette Blandine1, Sanjit Kumar2, Tchiégang Clergé1, MookambeswaranVijayalakshmi. An Aspartic metalloprotease from an Endemic Plant Tuber (Burnatia enneandra micheli): Purification and Biochemical Characterization. Pharmacognosy Magazine, DOI: 10.4103/pm.pm_555_17
  • Guntur Divya, N.S. Jayaprakash, and Krishnan Venkataraman. 2018. Development and Characterization of Monoclonal Antibodies Against Nitro-166Tyrosine of High-Density Lipoprotein: Apolipoprotein A1. Monoclonal antibodies in immunodiagnosis and immunotherapy (formerly Hybridoma). Volume 37, Number 4, 2018. DOI: 10.1089/mab.2018.0018
  • Ozhiparambil A Jagan, Gopi Manoj, N.S. Jayaprakash, Ramesh M Nair, Sara Chandy. 2018. Basal core Molecular Diversity of Hepatitis B Virus X Gene in Central Kerala, Southern India. Journal of Clinical and Diagnostic Research. 2018 Jun, Vol-12(6): DC10-DC14.
  • Venkatesh Padmanabhan, G. Arun Govind, A.S. Kamalanathan and N.S. Jayaprakash. Extraction of Antigenic Membrane Proteins from Salmonella Using Detergent and Phase Partition Method. 2018. Research Journal of Microbiology. 13 (1), 47-52


  • Ayesha Noor, Vijayalakshmi MA. 2017, Improvement of insulin secretion and pancreatic β-cell function in streptozotocin induced diabetic rats treated with Aloe vera extract. Phcog Res, 9(1), S99-104.
  • Verma R, Chandy S, Jayaprakash NS, Manoharan A, Vijayalakshmi MA, Venkataraman K. Diagnostic potential of monoclonal antibodies developed against C-terminal polypeptide of P. falciparum Histidine Rich Protein2 (PfHRP2) in malaria infected patients from India. Pathogens and Global Health. 2017, 111 (6); 297-305.
  • Chandy S, Kirubanandhan L, Hemavathy P, Khadeeja AM, Kurian SJ, Venkataraman K, Mørch K, Mathai D, Manoharan A. Serovar prevalence of Leptospira in semirural India and the development of an IgM-based indirect ELISA. J Infect Dev Ctries. 2017 Mar 31;11(3):234-241. doi: 10.3855/jidc.8067. PubMed PMID: 28368857.
  • Sharma M, Hotpet V, B R Sindhura, A S Kamalanathan, Swamy BM, Inamdar SR. Purification, Characterization and biological significance of mannose binding lectin from Dioscoreabulbifera bulbils. Int J Biol Macromol. 2017 Sep;102:1146-1155
  • S Fatima, T Anwar, N Ahmad, A Islam, P Sen. Non-enzymatic glycation enhances human serum albumin binding capacity to sodium fluorescein at room temperature: A spectroscopic analysis . Clinica Chimica Acta. 2017; 469/ 180-186
  • Javed Masood Khan, MohdShahnawaz Khan, Mohammad AbdurehmanAlsenaidy, Anwar Ahmed, Priyankar Sen, Mohammad Oves, Nasser Abdulatif Al-Shabib, Rizwan Hasan Khan. Sodium louroylsarcosinate (sarkosyl) modulate amyloid fibril formation in hen egg white lysozyme (HEWL) at alkaline pH: A molecular insight study. Journal of Biomolecular Structure and Dynamics. 2017; 1-48
  • S Fatima, P Sen, P Sneha, CG Priyadoss. Hydrophobic Interaction Between Domain I of Albumin and B Chain of Detemir May Support Myristate-Dependent Detemir-Albumin Binding. Applied Biochemistry and Biotechnology. 2017. 182 (1)/ 82-96
  • TN Shamsi, R Parveen, P Sen, S Fatima. Purification and characterization of a novel trypsin-like protease from green-seeded chickpea (Cicerarientum). Preparative Biochemistry and Biotechnology. 2017. 1-7.
  • Rajiniraja M., Sabareesh V., Saba Naz, Vinay K.N., Jayaraman G. Allium sativum Linn. contains linear alkylbenzene sulfonates that alter membrane fluidity for the inhibition of Mycobacterium tuberculosis H37Ra. Asian J. Pharm. Clin. Res. 2017, Vol. 10, Issue 9 (September Issue), p. 100-111.
  • Khaparde, A., Vijayalakshmi, M. A., Tetala, K. K. R., Development of metal/chelate poly HEMA monolith capillary for selective depletion of IgG from from human plasma for proteomic applications, J. Chromatogr. A, 2017, 1515, 117-125 .
  • Khaparde, A., Vijayalakshmi, M. A., Tetala, K. K. R., Preparation and characterization of Cu (II)-IDA poly HEMA monolith syringe for proteomic applications, Manuscript Accepted in Electrophoresis, DOI: 10.1002/elps.201700219.
  • Karan, K., Tetala, K. K. R., Vijayalakshmi, M. A. A structure based plasma protein pre-fractionation using conjoint immobilized metal-ion affinity (IMA) system.J. Chromatogr. B, 2017, 1052, 1-9.
  • V. Sabareesh, P. Boomathi Pandeswari, M.A. Vijayalakshmi. 2017. Arginine modification by 1,2-dicarbonyl compounds studied by liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS). J. Chromatogr. Sep. Tech., 8: 3(Suppl), p.56.
  • D. Sahal, V. Sabareesh. 2017. Explorations into isomeric peptides of opposite directionalities by tandem mass spectrometry. J. Chromatogr. Sep. Tech., 8: 3 (Suppl), p.93.
  • Sanjay Naik, Ravindra Singh Rawat, SantriptiKhandai, Mukesh Kumar, Sidhartha S. Jena, Mookambeswaran A Vijayalakshmi, Sanjit Kumar.Biochemical characterisation of lectin from indian hyacinth plant bulbs with potential inhibitory action against human cancer cells. International journal of biological macromolecules. 2017 Aug 7. pii: S0141-8130(17)31027-9. doi: 10.1016/j.ijbiomac.2017.07.170.
  • Ngangoum Eric Serge, Mezajoug Kenfack LauretteB landine,Tchiégang Clergé, Mookambeswaran Vijayalakshmi, Sanjit Kumar. Extraction, Purification and Biochemical Characterization of Protease from Leaves of Abrusprecatorius Preparative Biochemistry and Biotechnology 2017 Aug 31. doi: 10.1080/10826068.2017.1373289.
  • Kumar S,Imteyazqamar Singh N Non-steroidal Anti-inflammatory Drugs (NSAIDs) eLS Journal (Published Online: 20 MAR 2017) 2017. DOI: 10.1002/9780470015902.a0024221
  • B. Premkumar, N.S. Jayaprakash, M.A. Vijayalakshmi. 2017. Supermacroporus cryogel system – a supporting material for culturing hybridoma cells. International Journal for innovative pharmaceutical sciences and research 5(9). 22-31.


  • Ayesha Noor, V. Sabareesh, M.A. Vijayalakshmi. 2016, Preliminary screening of potential flavonoid-subclasses in Myristica fragrans and Cordyline terminalis by LC-ESI-MS.  Journal of Pharmacognosy and Phytochemistry 5(6): 437-450.
  • Ozhiparambil A Jagan, Gopi Manoj, N.S. Jayaprakash, G. Thomas, Sara Chandy. 2016. Molecular diversity of Hepatitis B virus (HBV) x gene: A preliminary report from Kerala. International Journal of Infectious Diseases, 455; Page 451.
  • Srividya Malkapuram, Swamini Taran, Krishnan Venkataraman and Lakshman Rajagopalan (2016). Green Coffee Extract Induces Activation Markers In J774.1 Macrophages and Protects them from Doxorubicin Induced Apoptosis. Int J Pharm Bio Sci 2016 Jan; 7(1): (P) 153 – 160.
  • Srividya Malkapuram, Krishnan Venkataraman, Rucha Tongaonkar, Swamini Taran, Lakshmisireesha Kolla and Lakshman Rajagopalan, (2016). Green Coffee Extract Protects H9C2 Cardiomyocytes from Doxorubicin Induced Apoptosis. Research Journal of Medicinal Plants, 10: 89-97. DOI: 10.3923/rjmp.2016.89.97.
  • Janakiraman VN, Noubhani MN, Venkataraman K, Vijayalakshmi M.A., Santarelli X, “High yield of recombinant human Apolipoprotein A-I expressed in Pichia pastoris by using mixed-mode chromatography.” Biotechnol J. (2016).11(1), 117-126.
  • Kishore K. R. Tetala, Vijayalakshmi, M. A. 2016. A review on recent developments for biomolecule separation at analytical scale using microfluidic devices. Analytica Chimica  Acta, 906 (2016) 7-21. 
  • Savane TS, Kumar S•, Janakiraman VN, Kamalanathan AS, Vijayalakshmi MA. 2016. Molecular insight in the purification of immunoglobulin by pseudobiospecific ligand l-histidine and histidyl moieties in histidine ligand affinity chromatography (HLAC) by molecular docking. J Chromatogr B Analyt Technol Biomed Life Sci. 1021, 129-136.
  • Parthasarathy, B., Sateeshkumar, P.K., Venkataraman,K., Vijayalakshmi, M.A. (2016). Periplasmic secretion, extraction and purification of recombinant tagless anti-Tumor Necrosis Factor (TNF) alpha single chain variable fragment (scFv) in E. coli. International Journal of Current Research. Vol.8 (02) 26014-26019.
  • Balaji P, Satheeshkumar PK, Venkataraman K, Vijayalakshmi MA. Expression of anti-tumor necrosis factor alpha (TNFα) single-chain variable fragment (scFv) in Spirodela punctata plants transformed with Agrobacterium tumefaciens. Biotechnol Appl Biochem. 2016 May;63(3):354-61. doi: 10.1002/bab.1373.
  • Gulamnabi L. Vanti, H. Vishwanathreddy, Hemalatha Venkat, Ganapati G. Bhat, Venkatesh Padmanabhan, N. S. Jayaprakash, Vamadevaiah Hiremath, Ishwarappa S. Katageri, Sathisha J. Gonchigar, Shashikala R. Inamdar, Bale M. Swamy. Sclerotium rolfsii lectin expressed in tobacco confers protection against Spodoptera litura and Myzus persicae. J Pest Sci. 89(2), June 2016, Pages 591-602.
  • Boomathi Pandeswari P., Sabareesh V., Vijayalakshmi M.A. "Insights into stoichiometry of arginine modification by phenylglyoxal and 1,2-cyclohexanedione probed by LC-ESI-MS". J. Proteins Proteomics 2016, Vol. 7, Issue 4: pp. 323 - 347.
  • Chandrasekhar Reddy B., Noor A., Sabareesh V., Vijayalakshmi M.A. "Preliminary screening of potential flavonoid-subclasses in Myristica fragrans and Cordyline terminalis by LC-ESI-MS". J. Pharmacognosy Phytochemistry 2016, Vol. 5, Issue 6: pp. 437 - 450.
  • Goud E.V., Das D., Sivaramakrishna A., Vijayakrishna K., Sabareesh V., Gopakumar G., Brahmmananda Rao C.V.S., Lone M.Y., Jha P.C. "Investigations on synthesis, coordination behavior and actinide recovery of unexplored dicyclohexylphosphinic acid". Polyhedron 2016, 117: 741–748.

Last update:18 June 2020



  • V. Sabareesh* and D. Sahal*, Explorations into isomeric peptides of opposite directionalities by high resolution electrospray collision induced dissociation tandem mass spectrometry, Int. J. Mass Spectrom. (2015) 391: 31 - 40.
  • R. Guleria, S. Pasha, G. Makharia and V. Sabareesh*, Understanding the response of the molecule to electrospray ionization (ESI) by selected reaction monitoring (SRM) tandem mass spectrometry: Defining Molecular ESI Index (MESII), Mass Spectrom. & Purif. Tech. (2015) 1: 104. (doi:10.4172/mso.1000104) Non-Scopus Publication.
  • Dwivedi AK, Gurjar V, Kumar S, Singh N. Molecular basis for nonspecificity of nonsteroidal anti-inflammatory drugs (NSAIDs). Drug Discov Today. 2015 Jul;20(7):863-73.
  • R. Ravichandran, S. Hemaasri, Swaranjit Singh Cameotra, N.S. Jayaprakash. 2015. Purification and characterization of an extracellular uricase from a new isolate of Sphingobacterium thalpophilum(VITPCB5). Protein Expression and Purification 114, October 2015, Pages 136–142.
  • Ravichandran R., Venkatesh Padmanabhan, M.A.Vijayalakhsmi, N.S. Jayaprakash*. 2015. Studies on recovery of lactoferrin from bovine colostrum whey using mercapto ethyl pyridine and phenyl propyl amine HyperCel™ mixed mode sorbents. Biotechnology and Bioprocess Engineering.  20(1):148-156 Feb 2015.
  • Reena Verma, Jayaprakash N.S, Vijayalakshmi. M.A, Krishnan Venkataraman. 2015. Novel monoclonal antibody against truncated C terminal region of Histidine Rich  Protein-2 (HRP2) and its utility for the specific diagnosis of malaria caused by Plasmodium falciparum. Experimental Parasitology 150: 56-66, March 2015.
  • K.K. Pulicherla and Mahendra Kumar Verma. Targeting therapeutics across the blood brain barrier (BBB), prerequisite towards thrombolytic therapy for cerebrovascular disorders- Overview and advancements. AAPS Pharm SciTech. Jan., 2015. ISSN:1530-9932.
  • Rajasekar R. Prasanna, Agamudi S. Kamalanathan and Mookambeswaran A. Vijayalakshmi. 2015. Development of l-histidine immobilized CIM® monolithic disks for purification of immunoglobulin G.  J of Molecular Recognition. January, 2015, 28:129-141.
  • Preetha RVijayan KKJayaprakash N.S., Alavandi SVSantiago TCBright Singh IS. 2015. Optimization of Culture Conditions for Mass Production of the Probiotics Pseudomonas MCCB 102 and 103 Antagonistic to Pathogenic Vibrios in Aquaculture. Probiotics Antimicrob Proteins. 7(2):137-45.


  • Ravichandran R., Venkatesh Padmanabhan, M.A.Vijayalakshmi, N.S. Jayaprakash. 2014. Studies on recovery of lactoferrin from bovine colostrum whey using mercapto ethyl pyridine and phenyl propyl amine HyperCel™ mixed mode sorbents. Biotechnology and Bioprocess Engineering.  (Accepted Sep 2014)
  • Manikandan K, Sabareesh V, Singh N, Saigal K, Mechold U, Sinha KM. 2014. Two-step synthesis and hydrolysis of cyclic di-AMP in Mycobacterium tuberculosis. PLoS One, 9(1): e86096.
  • Sabareesh V, Manikandan K, Sinha KM. 2014. Understanding dissociation of cyclic dinucleotide ions by electrospray mass spectrometry. Int. J. Mass Spectrom. 2014, 364: 9-15. Rajasekar R. Prasanna, Sinash Sidhik, Agamudi S. Kamalanathan, Krishna Bhagavatula, Mookambeswaran A. Vijayalakshmi. 2014. Affinity selection of histidine-containing peptides using metal chelate methacrylate monolithic disk for targeted LC–MS/MS approach in high-throughput proteomics. J of Chromatography B, Vol, 955-956, 1 April 2014, Pages 42-49.
  • L.N. Ramya and K.K. Pulicherla. Molecular insights into cold active polygalacturonase enzyme for its potential application in food processing. Journal of Food Science and Technology. Dec. 2014. ISSN: 0022-1155.
  • Suthakaran P, Jaiiamadhumithaa BS, Ravichandran M, Vidhyapriya M, Ramya LN, K.K. Pulicherla. Studies on Lipidification of Streptokinase: A novel Strategy to enhance the stability and activity. American Journal of Therapeutics. 2014 Sep-Oct;21(5):343-51. IF: 1.29. ISSN: 1075-2765.
  • Vijayanand A, Ramya LN, K.K. Pulicherla and KRSS Rao. Cold active pectinases: Advancing the food industry to next generation". Applied Biochemistry and Biotechnology, March 2014, Volume 172 (5), pp 2324-2337. IF: 1.94. ISSN: 0273-2289.
  • K. Srinivasa Babu, KK Pulicherla, Aju Antony and S. Meenakshi Sundaram. Cloning and expression of recombinant human GMCSF from Pichia pastoris GS115- a progressive strategy for economic production. American Journal of Therapeutics. 2014 Nov-Dec; 21: 462-469. IF: 1.29. ISSN:1075-2765.


  • Ayesha Noor, M. A. Vijayalakshmi. 2013, Current update on anti-diabetic biomolecules from key traditional Indian medicinal plants. Current Science, Vol. 104 (6), 25 MAR 2013, 721-727. 
  • Palani B., S.Shiva Ranjini, N.S. Jayaprakash, M.A.Vijayalakshmi.2013. Development, purification and characterization of monoclonal antibodies against recombinant histidine rich protein 3 (rHRP3) of Plasmodium  falciparum. Monoclonal antibodies in immunodiagnosis and immunotherapy. 32(5): 341-348.
  • Poonam Rajak, Vijayalakshmi M.A., Jayaprakash N.S. 2013. Production and characterization of monoclonal antibodies (mAbs) against human serum albumin (HSA) for the development of an immunoaffinity system with oriented anti-HSA mAbs as immobilized ligand. Journal of Pharmaceutical and Biomedical Analysis. 78-79, 154-160.
  • Sabareesh V, Singh G. 2013. Mass spectrometry based lipid(ome) analyzer and molecular platform: a new software to interpret and analyze electrospray and/or matrix-assisted laser desorption/ionization mass spectrometric data of lipids: a case study from Mycobacterium tuberculosis. J. Mass Spectrom. 48: 465-477.
  • Velusami, C.C.Agarwal, A.Mookambeswaran, A.V. 2013. Effect of nelumbo nucifera petal extracts on lipase, adipogenesis, adipolysis, and central receptors of obesity. Evidence-based Complementary and Alternative Medicine. Volume 2013, Article number 145925
  • Borsoi-Ribeiro, M.Bresolin, I.T.LVijayalakshmi, M.Bueno, S.M.A. 2013. Behavior of human immunoglobulin G adsorption onto immobilized Cu(II) affinity hollow-fiber membranes. J of Molecular Recognition. Volume 26, Issue 10, October 2013, Pages 514-520
  • Sudheer ReddySatheeshkumar, P.K.Vijayalakshmi, M.A. 2013. Expression, purification, and partial in vitro characterization of biologically active human coagulation factor VIII light chain (A3-C1-C2) in Pichia pastoris. Applied Biochemistry and Biotechnology Volume 171, Issue 1, September 2013, Pages 10-19.
  • V.P.B. Rekha, Mrinmoy Ghosh, K.K. Pulicherla and KRS Sambasiva Rao. Optimization of Polygalacturonase production from a newly isolated marine psychrophile Thalassospira frigidphilosprofundus to use in pectin hydrolysis - Statistical Approach. BioMed Research International. Volume 2013, Article ID 750187, IF: 2.883. ISSN: 2314-6133.
  • Anmol Kumar, K.K. Pulicherla, C. Mayuran, K Seetharam and KRS Sambasiva Rao. "Evaluation of a multifunctional staphylokinase variant with thrombin inhibition and antiplatelet aggregation activities produced from salt inducible E.coli GJ1158". Canadian Journal of Physiology and Pharmacology. Vol. 91: 839-847, 2013. IF: 1.94. ISSN: 0008-4212.
  • K.K. Pulicherla, Anmol Kumar, Gopi S. Gadupudi, K Seetharam and KRS Sambasiva Rao. "In vitro Characterization of a Multifunctional Staphylokinase Variant with Reduced Reocclusion, produced in an osmotically inducible E.coli GJ1158”. BioMed Research International. 2013. IF: 2.883. ISSN: 2314-6133
  • K.K. Pulicherla, P. Suresh Kumar, K. Manideep, VPB Rekha, Mrinmoy Ghosh and K.R.S. Sambasiva Rao. Statistical approach for the enhanced production of cold active β-galactosidase from Thalassospira frigidphilosprofundus: A novel marine psychrophile from deep waters of Bay of Bengal. Preparative Biochemistry and Biotechnology. Vol.43 (8): 766-780, 2013. IF: 0.562. ISSN:1082-6068


  • Poonam Rajak, M.A.Vijayalakshmi, N.S. Jayaprakash. 2012. Purification of monoclonal antibodies, IgG1, from cell culture supernatant by use of metal chelate convective interaction media (CIM) monolithic columns. Biomedical Chromatography. 26: 1488–1493.
  • Prem Kumar B, Poonam Rajak, M.A. Vijayalakshmi and N.S. Jayaprakash. 2012. Production of Human anti-glycophorin-A Monoclonal Antibodies and its Purification by Pseudoaffinity Chromatography using a Convective Interaction Media (CIM) monolithic column. Hybridoma, April 2012, 31(2), 105-110.
  • Priya S, Ayesha Noor, Sateeshkumar. 2012. Antioxidant and anti-proliferative activity of different solvent extracts of Casuarina equisetifolia needles. International Journal of Phytomedicine. Vol 4, No 1.
  • Sai Srikar Kandukuri, Ayesha Noor, Shiva Ranjini S, M.A Vijayalakshmi. 2012. Purification and characterization of catalase from sprouted black gram (Vigna mungo) seeds. ). J. Chromatography B, Vol. 889–890, 50-54.
  • Murugan, K., Iyer, V. V. 2012. Antioxidant and Antiproliferative activities of Marine Algae, Gracilaria edulis and Enteromorpha lingulata, from Chennai Coast. Int. J. Cancer Res. 8 (1), 15-26, ISSN 1811-9727/DOI: 10.3923/ijcr.2012.15.26.
  • Shiva Ranjini SVijayalakshmi MA. 2012. Study of Catalase adsorbtion on two mixed mode ligands and the mechanisms involved therein. J. Mol. Recognit; 25 (11):542-8 .
  • Deepa MSureshkumar TSatheeshkumar PKPriya S. 2012. Purified mulberry leaf lectin (MLL) induces apoptosis and cell cycle arrest in human breast cancer and colon cancer cells. Chem Biol Interact. 200(1):38-44.
  • Deepa S and Priya S. 2012. Purification and characterization of a novel anti-proliferative lectin from Morus alba L. leaves. Protein Pept Lett. 19(8):839-45.
  • Sureshkumar T and Priya S. 2012. Purification of a lectin from M. rubra leaves using immobilized metal ion affinity chromatography and its characterization. Appl Biochem Biotechnol, 168(8):2257-67.
  • Chuvappumkal Joseph Bilgimol, Sulochana Priya and Padikara Kutty Satheeshkumar. 2012. Detection of flavones in plants using PCR based approach. J of Nat. Prod & Plant Resou., 12,(2);298-301.
  • Sushma K, Biljimol CJ, Vijayalakshmi MA and Satheeshkumar P. K. 2012. Recovery of active anti TNF alpha ScFv through matrix-assisted refolding of bacterial inclusion bodies using CIM monolithic support. J Chrom. B. 1;891-892:90-3.


  • Ayesha Noor, M. A. Vijayalakshmi 2011. Antioxidant properties of Cordyline terminalis (L.) Kunth and Myristica fragrans Houtt. Encapsulated separately into casein beads. Current Science, Vol. 101, No. 2, 416-420.
  • Sushma K, Vijayalakshmi MA, Krishnan V and Satheeshkumar P. K. 2011. Cloning, expression, purification and characterization of a Single chain variable fragment specific to Tumor Necrosis Factor Alpha in Escherichia coli. J. Biotechnol. 156(4), 238-244.
  • Masaldan, S; Iyer, V. V. 2011. Antioxidant and antiproliferative activities of a methanolic extract of Aloe vera leaves in human cancer cell lines. J. Pharmacy Res. 4 (8), 2791-2796.
  • Roopa K.G., Mishra S. and Vijayalakshmi M.A. 2011. Purification of β-glucosidases from Pichia etchellsii using CIM Monolith columns. Applied Biochemistry and Biotechnology. 164: 68-76.
  • Singh S, Roy S, Sethi S, Benjamin B, Sundaram S, Khanna V, Kandalkar SR, Pal C, Kant R, Patra AK, Rayasam G, Mittra S, Saini KS, Paliwal J, Chugh A, Ahmed S, Sattigeri J, Cliff I, Ray A, Bansal VS, Bhatnagar PK, Davis JA. 2011. RBx-0597, a potent, selective and slow-binding inhibitor of dipeptidyl peptidase-IV for the treatment of type 2 diabetes. Eur J Pharmacol. 652(1-3):157-63.


  • Ayesha Noor, M.A. Vijayalakshmi. 2010, Free radical scavenging enzymes from two Fabaceae plants. Journal of Biotechnology, 150S, 64.
  • A.P. Dhivya, B. Prem Kumar, Rajasekar R. Prasanna, N.S. Jayaprakash and M.A. Vijayalakshmi. 2010. Purification of Monoclonal Antibodies from Cell-Culture Supernatant by use of Anion-Exchange Convective Interaction Media (CIM) Monolithic Columns. Chromatographia, 72 (11), 1183-1188.
  • Preetha R, Seena J, Sreedharan P, Vijayan K.K, Jayaprakash N.S., Rosamma Philip and Bright Singh I.S. 2010. An inhibitory compound produced by Pseudomonas with effectiveness on Vibrio harveyi. Aquaculture Research, 41(10), 1452-1461.
  • Somnath Pai, Anas A, Jayaprakash N.S., Priyaja P, Sreelakshmi B, Preetha R, Rosamma Philip, Mohandas A and Bright Singh I.S. 2010. Penaeus monodon larvae can be protected from Vibrio harveyi infection by pre-emptive treatment of a rearing system with antagonistic or non-antagonistic bacterial probiotics. Aquaculture Research, 41(6), 847-860.
  • Shiva Ranjini Srinivasan, Sai Srikar Kundukuri, Ayesha Noor, M.A. Vijayalakshmi. 2010. Free radical scavenging enzymes from two Fabaceae plants. Journal of Biotechnology, 150S (S1-S576), (doi:1001016/j.jbiotech.2010.08.168).
  • Bresolin IT, Borsoi-Ribeiro M, Tamashiro WM, Augusto EF, Vijayalakshmi MA, Bueno SM. 2010. Evaluation of immobilized metal-ion affinity chromatography (IMAC) as a technique for IgG(1) monoclonal antibodies purification: the effect of chelating ligand and support. Appl Biochem Biotechnol. 160(7):2148-65.
  • Ranjini SS, Bimal D, Dhivya AP, Vijayalakshmi MA. 2010. Study of the mechanism of interaction of antibody (IgG) on two mixed mode sorbents. J Chromatogr B Analyt Technol Biomed Life Sci. 878(15-16):1031-7.
  • Prabhu A, Sujatha DI, Ninan B, Vijayalakshmi MA. 2010. Neutrophil Gelatinase Associated Lipocalin as a Biomarker for Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Grafting with Cardiopulmonary Bypass. Ann Vasc Surg. 24(4): 525-31.
  • Prasanna RR, Vijayalakshmi MA. 2010. Characterization of metal chelate methacrylate monolithic disk for purification of polyclonal and monoclonal immunoglobulin G. J Chromatogr A. 1217(23):3660-7.
  • Sushma K., Satheeshkumar P.K, Krishnan V and Vijayalakshmi M.A. 2010. Recombinant anti-TNF alpha Scfv; a potential replacement candidate for anti-TNF alpha antibodies. Journal of Biotechnology, Proceedings, 2010.
  • Dehkharghanian M, Adenier H and Vijayalakshmi MA. 2010. Study of flavanoids in aqueous spinach extract using positive electrospray ionization tandem quadrupole mass spectrometry. Food Chemistry. 121; 863-870.
  • Prasanna RR, Vijayalakshmi MA. 2010. Immobilized metal ion affinity systems for recovery and structure function studies of proteins at molecular, supramolecular and cellular levels. Pure and Appl. Chem. 82(1), 39-55.


  • Kamalanathan A.S. and M.A Vijayalakshmi. 2009. Molecular studies of rheumatoid factor using pseudobioaffinity membrane chromatography. J. Mol. Recog. 22(2), 146-153.
  • Satheesh Babu A.K. and M.A Vijayalakshmi. 2009. Downstream processing of value-added proteins in biotechnology: An Indian scenario. Biotechnology Journal. 4(8):1132-9.
  • Prabhu A., Sujatha D.I., Kanakarajan N., Vijayalakshmi M.A. and N. Benjamin. 2009. Effect of N-Acetyl Cysteine in attenuating ischemic reperfusion injury in patients undergoing coronary artery bypass grafting with cardio pulmonary bypass. Annals of Vascular Surgery. 23(5):645-51.
  • Dehkharghanian M, Lacroix M and Vijayalakshmi MA. 2009. Antioxidant properties of green tea polyphenols encapsulated in caseinate beads. Dairy Science Technology. 89; 485-489.