Centre for Biomaterials, Cellular and Molecular Theranostics (CBCMT)

Antimicrobial Studies Laboratory

This laboratory has all the basic equipments needed to perform anti-microbial studies.

Lab in-charge: Dr.Raunak Kumar Das, Email: raunakkumardas@vit.ac.in

INSTRUMENTNAMECOMPANYNUMBER
LAMINAR AIR FLOW HOODCLEAN AIR1
SHAKER INCUBATORREMI1
REFRIGERATORWHIRLPOOL1

Biomaterials Processing Laboratory

Key challenges in the field of implantology are stress shielding, low fatigue strength, poor bone bonding and formation of biofilim on implants. This laboratory has all the basic equipments needed for the development of materials with tailored mechanical properties. Materials with grain size ranging from micron and to nano are being investigated to have optimum modulus closer to bone and high fatigue and mechanical strength. Two high temperature furnaces with controlled environment is available to facilitate this work. In addition, novel coatings to improve the osseointegration and prevent bacterial formation are developed using simple cost-effective techniques such as Electrophoretic deposition (EPD) and micro arc oxidation (MAO). In addition, this laboratory also involves activities related to replacement and reconstruction of diseased or damaged parts of the musculo-skeletal/dental systems by near net shape manufacturing of implants using different material and biological characterizations. Further, this lab focuses on development of new generation of ceramic, ceramic- polymeric/metallic composites for different biomedical applications. A substantial portion of this lab is involved in colloidal process of ceramics, bio-ceramics, protein coagulation casting, sol-gel and implant designing (dental and maxillofacial prosthesis) for bio-medical applications.

Lab In-charge: Dr.Suya Prem Anand, Email: suyapremanand.p@vit.ac.in

INSTRUMENT NAMECOMPANYNUMBER
Plasma CleanerFillunger1
Tubular FurnaceVB Ceramics1
Box FurnaceVB Ceramics1
Slow speed diamond sawChennai Metco2
Hot air ovenTHE.I.L.E.CO1
Disc polishing machineChennai Metco1
Mounting MachineChennai Metco1
 

HOME Lab (3D Bioprinting Laboratory)

3D bioprinting facilities are a recent addition to our centre. The advanced 3D bioprinting facility is called HOME (Human Organ Manufacturing and Engineering) Lab, equipped with two high-end Cellink BioX bioprinter as well as few basic bioprinters. With this addition, the centre is better positioned to fabricate 3D organoids and tissue mimics, which will be also be one of the key focus areas in coming years.

Lab In-charge: Dr.Arunkumar Palaniappan, Email: arunkumar.p@vit.ac.in

INSTRUMENTNAME COMPANY NUMBER
3D BIOPRINTER WITH PNEUMATIC HEAD CELLINK 1
3D BIOPRINTER FOR THERMOPLASTIC POLYMERS CELLINK 1
ALFATEK 3D BIOPRINTER ALFATEK 2
BSL2 BIOSAFETY CABINET ESCO BIOTECH 1
CO2 INCUBATOR ESCO BIOTECH 1
INVERTED MICROSCOPE MAGNUS 1
COOLING CENTRIFUGE REMI 2
ANALYTICAL BALANCE SARTORIOUS 1
DIGITAL 5 POSITION MAGNETIC STIRRER REMI 1
MAGNETIC STIRRER TARSON 1
PH METER SYSTRONICS 1
FREEZE DRIER MARTIN CHRIST 1
VORTEX MIXER REMI 1
MICROBALANCE SHIMADZU-UNIBOC 1
SPINWIN MICRO CENTRIFUGE TARSON 1
CLINICAL CENTIFUGE REMI 1
HOT AIR OVEN TECHNICO LAB PRODUCT 1
AUTOCLAVE BIOTECH ENGINEERING 1
REFRIGERATOR LG 1

Medical Physics Laboratory

This laboratory has all the basic equipments needed to perform experiments related to medical physics applications. Medical Physics is the application of Physics concepts, theories and principles to medicine or health care.Some of the key areas of research include:

  • Radiation Physics
  • Growth and characterization of urinary crystals (Invitro and Invivo)
  • Ultrasonics
  • Biomechanics & Biomaterial characterization
  • Synthesis and characterization of magnetic nanoparticle for Hyperthermia application
  • Biophotonics

Lab In-charge: Dr.Arunai Nambi Raj, Email: narunainambiraj@vit.ac.in

INSTRUMENTNAMECOMPANYNUMBER
MATERIAL TESTING MACHINEH5KS, TINIUSOLSEN, UK1
G4 SENSOR HUBPOLHEMUS, USA1
RADIOFREQUENCY DAMPING ANALYSERIMCE, BELGIUM1
PIEZOELECTRIC OSCILLATORMITTAL ENTERPRISES,INDIA1

Cellular and Molecular Therapeutics Laboratory

CMTL is a laboratory focusing on developing creative approaches uniting diagnosis and therapy for various diseases, particularly those with significant unmet medical needs.

This lab is used to perform cell-based studies like cytotoxicity, biocompatibility and various molecular and cellular assays for identifying the unique characteristics of a disease and help bridge the gap between identification of disease and application of therapy.

Person to contact: Prof. Amit Kumar Jaiswal, Email: amitj@vit.ac.in

CMTL lab equipment list

The Bio-Rad iMark Microplate Reader is a versatile absorbance microplate reader. It is optimized for 96-well microplates and offers excellent performance with features that ensure reliability and accuracy.

The Takara PCR Thermal Cycler is a high-performance device used for polymerase chain reaction (PCR) amplification of DNA.

The Eppendorf BioPhotometer D30 is a compact, reliable, and user-friendly spectrophotometer with a wide wavelength range. It measures the concentration and purity of biomolecules, such as nucleic acids (DNA and RNA) and proteins, using UV-visible spectrophotometry

The UVP ChemiDoc-It² Imager is an advanced imaging system designed for high-sensitivity detection and analysis of chemiluminescent blots, fluorescent gels, and stained proteins.

The Quantitative Real-Time PCR (qPCR) system is an advanced instrument designed for precise and reliable quantification of nucleic acids in real time.

A luminometer is a sensitive and versatile instrument designed for luminescence-based measurements. It works by detecting photons of light emitted from a chemical or enzymatic reaction.

Cell culture facility contains biosafety cabinet, incubator, centrifuge and inverted microscope. The facility can be used for assessment of  biocompatibility and to perform various cellular assays.

Tissue Engineering Laboratory

This facility has all the basic equipments needed to fabricate polymeric scaffolds, hydrogels and nanomaterials which are crucial for tissue engineering lab.

Lab in-charge: Dr.Amit Kumar Jaiswal, Email: mailto:amitj@vit.ac.in

INSTRUMENT NAME COMPANY NUMBER
SHAKER INCUBATOR REMI 1
REFERIGIRATOR SAMSUNG/LG/REMI 3
BSL2 BIOSAFETY CABINET ESCO BIOTECH 1
CO2 INCUBATOR ESCO BIOTECH 1
INVERTED MICROSCOPE MAGNUS 1
COOLING CENTRIFUGE REMI 2
ANALYTICAL BALANCE SARTORIOUS 1
DIGITAL 5 POSITION MAGNETIC STIRRER REMI 1
MAGNETIC STIRRER TARSON 1
PH METER SYSTRONICS 1
FREEZE DRIER MARTIN CHRIST 1
HOT PLATE WITH MAGNETIC STIRRER REMI 1
SPINIX ORBITAL SHAKER TARSON 1
VORTEX MIXER REMI 1
MICROBALANCE SHIMADZU-UNIBOC 1
SPINWIN MICRO CENTRIFUGE TARSON 1
CLINICAL CENTIFUGE REMI 1
HOT AIR OVEN TECHNICO LAB PRODUCT 1
ELISA PLATE READER LEADS INDIA LABORATORY EQUIPMENTS INC. 1
-20 FREEZER CRYOSCIENTIFIC 1
DOUBLE DISTILLATION UNIT AIR BLOW 1
BACTERIOLOGICAL INCUBATOR LARK 1
AUTOCLAVE BIOTECH ENGINEERING 1
ELECTROSPINNING SETUP ESPIN 1
MILLIPORE® DIRECT®-Q 3 WITH UV WATER PURIFIER MERCK 1

Confocal Microscopy Facility

Biocorrosion and Biotribology Laboratory

Corrosion and wear are the major factors that affects the service period of an implant when exposed to the aggressive environment as in human body. Development of new materials and coatings to alleviate wear and corrosion are the major focus of biomaterials research to enhance the longevity of mankind. The major focus of this facility is to evaluate and understand the behaviour of widely used implant materials such as titanium and magnesium in simulated body conditions. The corrosion of coated and uncoated substrates are evaluated using ACM Gill potentiostat under controlled environment. A reciprocator wear tester (Ducom) with temperature, pH and environment-controlled equipment is utilized to assess wear rate and friction of materials. The scratch resistance of the thin film coatings is measured using either a static or ramp loaded scratch tester provided with 200 µm dia diamond indenter.

Lab In-charge: Dr.Mohan Varma Damu Seshadri, Email: mohanvarma@vit.ac.in
Instrument nameCompanyNumber
Fretting wearDucom Instruments1
Reciprocating wear testDucom TR-285-M11
Scratch testerDucom1
PotentiostatACM-GillAC1
Contact angle measuring systemHolmarc Opto-Mechatronics Pvt. Ltd.1
Optical Microscope Carl Zeiss1
Vickers hardness testerChennai Metco Pvt Ltd1
Electrophoretic depositionAPLAB L12851
Fume hoodModern Lab Interior2

Drug Discovery Unit

The Drug Discovery Unit (DDU) was established in 2020 and is a part of the Centre for Biomaterials, Cellular, and Molecular Theranostics (CBCMT), VIT, Vellore. The core aim of DDU is to find innovative basic science findings and initiate preclinical drug discovery and development, translating them into the bedside. Currently, DDU is actively involved in research on developing small molecule drug design and discovery, fluorescent imaging agents for assisting cancer surgery, developing proteolysis targeting chimera (PROTAC) for cancer therapy, finding small molecules for cancer immunotherapy, developing dual-targeting agents to selectively target cancer cells, developing photosensitizers for cancer therapy, therapeutics agents for various disease such as diabetes, antimicrobial resistance, cardiovascular diseases, tuberculosis, and fibrosis, etc. and developing biotherapeutics such as miRNA, siRNA and protein-based therapeutics.

Lab In-charge: Dr. Loganathan Rangasamy , Email: loganathan.r@vit.ac.in

Preparative Binary Gradient HPLC with Autosampler Company: Shimadzu Model: SIL -20ACHT

Flash Chromatography Company : Teledyne ISCO Model: Combi flash Nextgen 100

Rotatory Evaporator Company: Heidolph Model: Hei-VAP Core HL

Computational Workstation Software: SeeSAR - Everyday Drug Design Dashboard, and StarDrop Small Molecule Drug Discovery

Microbalance Company: Shimadzu Model: Uni Bloc

Oscillating Hydrogenator

Wrist Action Shaker

Laboratory Peptide Shaker Company: Kamush Model: LP – Shaker 360 AMPv

OTHER FACILITIES

Fume Hood

Hot Air Oven

Centrifuge

Vortex Mixer

UV Cabinet

Magnetic Stirrer

Ultrasonic Cleaner

Heating Mandle

pH Meter

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